Metabolic syndrome linked to colon cancer

“Although metabolic syndrome {a cluster of conditions that affects one in five American adults and which can include diabetes, obesity, high blood pressure, low levels of good cholesterol and high amounts of lipids in the blood} has been linked to colon cancer, the third leading cause of cancer death in the U.S., previous work looking at its effect on mortality has not adequately accounted for cancer stage or treatment,” said senior author Nestor Esnaola, MD, MPH, MBA, Chief of the Division of Surgical Oncology, Professor of Vice-Chair of Clinical and Academic Affairs in the Department of Surgery at Temple University School of Medicine. “Our results suggest that patients with early stage colon cancer who also have diabetes or hypertension may need to be followed more closely for recurrence and could potentially benefit from broader use of adjuvant chemotherapy.” Dr. Esnaola and his team reported their findings December 20, 2012 in an early online publication in the journal CANCER.

Endoscopic image of colon cancer identified in...

Endoscopic image of colon cancer identified in the sigmoid colon on screening colonoscopy for Crohn’s disease (Photo credit: Wikipedia)

The researchers found that among patients with early stage disease, patients with diabetes or high blood pressure had a significantly greater risk of cancer recurrence rate and death after treatment. For example, 47.7 percent of patients who did not have diabetes were still alive five years after diagnosis compared to only 41.3 percent of patients with diabetes. When the researchers looked more closely, they also found that cancer recurrence rates at five years were approximately 8 percent higher in patients with diabetes or hypertension.

In contrast, the analysis showed that patients with abnormally high levels of lipids in the blood had a lower risk of recurrence and death from colon cancer. Overall, 39 percent of patients with normal lipid levels were still alive after five years, compared to 52.7 percent of patients with abnormal levels. Cancer recurrence rates were approximately 11 percentage points lower in patients with abnormal lipid levels.

Read morein the Journal Cancer and in: Temple researcher shows diabetes, blood pressure link to colon cancer recurrence, survival



  • Unhealthy Snacks Tied to Colon Cancer for Those at High Risk (
    Previous research has shown that consuming alcohol and red and processed meats can increase the risk of cancer in people with Lynch syndrome. Smoking and obesity are other possible risk factors.
  • Colon Cancer Survival Statistics and Results (
    cancer is a complex disease and each person’s medical condition is different; therefore, CTCA makes no claims about the efficacy of specific treatments or the delivery of care and not all cancer patients who are treated at a CTCA hospital may experience these same results.
  • Colon Cancer: Integrative Treatment Program (
    Watch a medical animation that illustrates the function of the colon, and how cancer can develop from malignant polyps or tumors in its lining.A Team Approach to Colon Cancer TreatmentOur experts use many tools to help you fight cancer of the colon on all fronts.
  • Colon Cancer Symptoms & Signs (
    Listen to Dr. Leon Yoder explain how doctors diagnose colon cancer, often with a colonoscopy to biopsy an abnormal polyp, followed by an endoscopic ultrasound to stage the tumor.What Are the Symptoms of Colon Cancer?Colon polyps may begin as benign tumors and develop into cancer.
  • Fighting Colon Cancer (
    Researchers found a specific pattern of VOCs in colon cancer patients that was not present in the healthy group. They then analyzed the breath of 25 additional people using the VOC pattern to try to identify those with colon cancer. The overall accuracy rate for diagnosis was 76 percent.
  • Increasing Appetite in Colon Cancer Patients (
    If you’re caring for someone with a cancer that has progressed, such as advanced colon cancer, you probably have noticed the weight loss. Some of this weight loss isn’t related to not eating or lack of appetite (anorexia), but to the loss of muscle mass, called cachexia.
  • Higher Dietary Glycemic Load Linked To Worse Colon Cancer Survival (
    The role of one’s lifestyle behavior has been shown to play an important role in the development of colorectal cancer. Risk factors, such as obesity and physical activity have been shown to directly influence insulin levels and recent studies have shown a direct link between host factors that lead to hyperinsulinemia and cancer recurrence and mortality in colorectal cancer survivors; however, the influence of glycemic load and other related dietary intakes have on the survival of colon cancer patients is unknown.
    The researchers found that increasing dietary glycemic load and total carbohydrate intake where both linked with increased cancer recurrence and death and survival of the patients had a distinct correlation with overweight and obese patients. “Given that patients who consume high glycemic loads or carbohydrates after cancer diagnosis may have consumed a similar diet before diagnosis, we cannot exclude the possibility that individuals with these dietary exposures acquire tumors that are biologically more aggressive.”
  • Colon Cancer Patients Who Consume Too Much Starchy, High Carbohydrate Food At Greater Risk For Cancer Recurrence (
    Colon cancer survivors whose diet is heavy in complex sugars and carbohydrate-rich foods are far more likely to have a recurrence of the disease than are patients who eat a better balance of foods, a new study by Dana-Farber Cancer Institute researchers indicates.
    High insulin levels can be produced by eating too many starchy and sugar-laden foods. In a previous study of advanced-stage colon cancer patients, Meyerhardt and his colleagues found that those with a typical “Western” diet — marked by high intakes of meat, fat, refined grains, and sugar desserts — were three times more likely to have a cancer recurrence than those whose diets were least Western.
  • Lynch Syndrome (Hereditary Nonpolyposis Colon Cancer) (
    even though the tumors are poorly differentiated, they have a better prognosis than sporadicallly occurring tumors
  • Well: Can Foods Affect Colon Cancer Survival? (
    people treated for Stage 3 disease, in which tumor cells have spread to lymph nodes, had greatly increased chances of dying of it or experiencing a recurrence if their diets were heavy in carbohydrate-rich foods that cause spikes in blood sugar and insulin.

About Marcus Ampe

Retired dancer, choreographer, choreologist Founder of the Dance impresario office and archive: Danscontact-Dansarchief plus the Association for Bible scholars, the Lifestyle magazines "Stepping Toes" and "From Guestwriters" and creator of the site "Messiah for all". - Gepensioneerd danser, choreograaf, choreoloog. Stichter van Danscontact-Dansarchief plus van de Vereniging voor Bijbelvorsers, de Lifestyle magazines "Stepping Toes" en "From Guestwriters" en maker van de site "Messiah for all".
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2 Responses to Metabolic syndrome linked to colon cancer

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  2. Pingback: 2015 Health and Welfare | Marcus Ampe's Space

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